What is Inflammation?
IT IS THE BODY’S NATURAL IMMUNE RESPONSE TO AN IRRITANT/INFECTIOUS PATHOGEN
(BACTERIA, FUNGI, VIRUSES, AND PARASITES), INJURY, OR ILLNESS.
Good Vs. Bad
The above-listed causes of inflammation activate a cascade of responses, involving many different types of immune cells. The immune cells in turn release inflammatory mediators including histamine and bradykinin, which leads to vasodilation (dilatation of blood vessels in the tissues). Vasodilation increases the local blood supply, which allows more immune cells to migrate to the injured tissue hastening the healing process. The inflammatory mediators also make it easier for the immune cells to pass through the walls of the blood vessels allowing increased entry of immune cells to the affected tissue.
While inflammation usually helps the body; in certain diseases (namely, autoimmune diseases) the body’s immune system targets the body’s cells (most of the time because of chronic dysbiosis) causing adverse inflammation.
What is our Gut Microbiome?
The gut microbiota is essentially a community of bacteria residing in our intestine. The usual concentrations of these bacteria are high in the saliva and the teeth (10 9 /ml and 10 11 /ml respectively) decreasing towards the stomach about 1000-10,000/mL (on account of the relatively low pH in the stomach and the relatively fast emptying of the content from the stomach to the duodenum). The concentration progressively increases through the different parts of the small intestine, reaching a new peak of 10 11 /ml in the colon (large intestine).
Which are the Main Bacteria That Make up Our Gut Microbiome?
The main phyla include:
The three major phyla of the above that live in our digestive tract are
Firmicutes, Actinobacteria, and Bacteroidetes.