What Is Ammonia?
Ammonia is a nitrogen and hydrogen compound that is produced by many animals,
smells (sweat and urine can reek of ammonia and its byproducts), and has many
industrial uses in our modern world.
Ammonia is a normal by-product of amino acid catabolism and
gluconeogenesis that is normally filtered by our kidneys then excreted in urine.
Our body metabolizes ammonia into urea known as the urea cycle. The urea cycle
occurs in the liver hepatocyte mitochondria and cytosol where ammonia is
converted into carbamoyl phosphate than urea. The urea is then released into the
bloodstream where it is filtered by the kidneys and eliminated from the body
through urination.
Ammonia's Purpose
Ammonia does serve a purpose for homeostasis; it is important for the natural
acid/alkaline balance in our body. Metabolism of amino acids produces a lot of
acid in the body. The high amount of protein in the standard American diet cause
the kidneys and pancreas to have a difficult time producing and reabsorbing
enough bicarbonate to maintain our body’s natural pH levels. Renal bicarbonate
generation requires proper ammonia metabolism to help the kidneys maintain
proper pH levels.
Symptoms
● Headaches
● Brain fog
● Confusion
● Insomnia
● Slurred speech
● Increased extracellular brain glutamate levels by reacting with the α-
ketoglutarate to form glutamate (can lead to seizures, visual snow, and mental
issues [schizophrenia, mania, psychosis])
● Irritability
● Elevated stomach pH
● Anxiety
● Mitochondrial dysfunction (ammonia inhibits mitochondrial dehydrogenases
and mitochondrial energy metabolism, collapsing mitochondrial membrane
potential and increases oxidative stress formation in the electron transport
chain)
● Poor fat metabolism from liver health issues● Fatigue by depleting α-ketoglutarate interfering with the Krebs cycle and
mitochondrial energy production.
● Muscle weakness
● Loss of appetite
● Nausea
● Vomiting
● Back or abdominal pain
● Foamy and cloudy urine
● Burning sensation when breathing and troubled breathing
Ammonia, like many metabolism byproducts (including hydrogen sulfide), are
toxic in large quantities when our body is unable to metabolize them but are
necessary for homeostasis.
Our Protocol & Restoration Kit
Fixing Your Gut
Fixing your gut is one of the first steps you should do to work on reducing your ammonia burden. Most people with gut issues that are dealing with hyperammonemia need to reduce the overgrowth they are dealing with.
Kidney & Liver Health
Our supplements in our kit are aimed to promote the health of your kidney and liver in order to help eliminate excess ammonia you may have. This kit will help you restore your score for Ammonia.
Fix It All
Ammonia is an endogenous byproduct of our daily life. However, when we suffer from weak liver, kidney, or digestive health ammonia can build up and cause ill
health. For most people with hyperammonemia, their issues stem from gut dysbiosis that produces too much for their body to handle.